Performance Analysis of Deep-Learning and Explainable AI Techniques for Detecting and Predicting Epileptic Seizures

Main Article Content

Ashwini Patil
Megharani Patil

Abstract

Epilepsy is one of the most common neurological diseases globally. Notably, people in low to middle-income nations could not get proper epilepsy treatment due to the cost and availability of medical infrastructure. The risk of sudden unpredicted death in Epilepsy is considerably high. Medical statistics reveal that people with Epilepsy die more prematurely than those without the disease. Early and accurately diagnosing diseases in the medical field is challenging due to the complex disease patterns and the need for time-sensitive medical responses to the patients. Even though numerous machine learning and advanced deep learning techniques have been employed for the seizure stages classification and prediction, understanding the causes behind the decision is difficult, termed a black box problem. Hence, doctors and patients are confronted with the black box decision-making to initiate the appropriate treatment and understand the disease patterns respectively. Owing to the scarcity of epileptic Electroencephalography (EEG) data, training the deep learning model with diversified epilepsy knowledge is still critical. Explainable Artificial intelligence has become a potential solution to provide the explanation and result interpretation of the learning models. By applying the explainable AI, there is a higher possibility of examining the features that influence the decision-making that either the patient recorded from epileptic or non-epileptic EEG signals. This paper reviews the various deep learning and Explainable AI techniques used for detecting and predicting epileptic seizures  using EEG data. It provides a comparative analysis of the different techniques based on their performance.

Article Details

How to Cite
Patil, A. ., & Patil, M. . (2023). Performance Analysis of Deep-Learning and Explainable AI Techniques for Detecting and Predicting Epileptic Seizures. International Journal on Recent and Innovation Trends in Computing and Communication, 11(9), 314–327. https://doi.org/10.17762/ijritcc.v11i9.8357
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References

G. Alarcon and A. Valentin, “Introduction to Epilepsy”, Cambridge University Press, Cambridge, UK, 2012.

M. Sazgar and M. G. Young, “Absolute Epilepsy and EEG Rotation Review: Essentials for Trainees”, Springer, Berlin, Germany, 2019.

Amrani, G., Adadi, A., Berrada, M., Souirti, Z., & Boujraf, S. “EEG signal analysis using deep learning: A systematic literature review”, 2021 Fifth International Conference on Intelligent Computing in Data Sciences (ICDS), 2021

Ahmad, I., Wang, X., Zhu, M., Wang, C., Pi, Y., Khan, J. A., Khan, S., Samuel, O. W., Chen, S., & Li, G. “EEG-based epileptic seizure detection via machine/deep learning approaches: A systematic review”, Computational Intelligence and Neuroscience, 2022, 6486570. https://doi.org/10.1155/2022/6486570

Ein Shoka, A. A., Dessouky, M. M., El-Sayed, A., & Hemdan, E. E.-D. “EEG seizure detection: concepts, techniques, challenges, and future trends. Multimedia Tools and Applications”, 1–31, 2023. https://doi.org/10.1007/s11042-023-15052-2

Yuan, J., Ran, X., Liu, K., Yao, C., Yao, Y., Wu, H., & Liu, Q. “Machine learning applications on neuroimaging for diagnosis and prognosis of Epilepsy: A review. Journal of Neuroscience Methods”, 368(109441), 2022, 109441. https://doi.org/10.1016/j.jneumeth.2021.109441

Hernández, M., Canal-Alonso, Á., de la Prieta, F., Rodríguez, S., Prieto, J., & Corchado, J. M. “Machine learning and deep learning techniques for epileptic seizures prediction: A brief review”. In Practical Applications of Computational Biology and Bioinformatics, 16th International Conference (PACBB 2022) (pp. 13–21), 2023. Springer International Publishing.

Spencer, D. D., Gerrard, J. L., & Zaveri, H. P. “The roles of surgery and technology in understanding focal Epilepsy and its comorbidities”. Lancet Neurology, 17(4), 373–382, 2018. https://doi.org/10.1016/S1474-4422(18)30031-0

Islam, M. U., Mozaharul Mottalib, M., Hassan, M., Alam, Z. I., Zobaed, S. M., & Fazle Rabby, M. “The past, present, and prospective future of XAI: A comprehensive review”. In Studies in Computational Intelligence (pp. 1–29), 2022. Springer International Publishing.

Tjoa, E., & Guan, C. “A survey on explainable artificial intelligence (XAI): Toward medical XAI”, IEEE Transactions on Neural Networks and Learning Systems, 32(11), 4793–4813, 2021. https://doi.org/10.1109/TNNLS.2020.3027314

Rathod, P., & Naik, S. “Review on epilepsy detection with explainable artificial intelligence”. 2022 10th International Conference on Emerging Trends in Engineering and Technology - Signal and Information Processing (ICETET-SIP-22).

Alsaleh, M. M., Allery, F., Choi, J. W., Hama, T., McQuillin, A., Wu, H., & Thygesen, J. H. “Prediction of disease comorbidity using explainable artificial intelligence and machine learning techniques: A systematic review”, International Journal of Medical Informatics, 175(105088) 2023, 105088, ,https://doi.org/10.1016/j.ijmedinf.2023.105088

Hossain, M. S., Amin, S. U., Alsulaiman, M., & Muhammad, G. “Applying deep learning for epilepsy seizure detection and brain mapping visualization”, ACM Transactions on Multimedia Computing Communications and Applications, 15(1s), 1–17, 2019. https://doi.org/10.1145/3241056

Li, Y., Liu, Y., Cui, W.-G., Guo, Y.-Z., Huang, H., & Hu, Z.-Y. “Epileptic seizure detection in EEG signals using a unified temporal-spectral squeeze-and-excitation network”. IEEE Transactions on Neural Systems and Rehabilitation Engineering: A Publication of the IEEE Engineering in Medicine and Biology Society, 28(4), 782–794, 2020. https://doi.org/10.1109/TNSRE.2020.2973434

Tang, F.-G., Liu, Y., Li, Y., & Peng, Z.-W. “A unified multi-level spectral–temporal feature learning framework for patient-specific seizure onset detection in EEG signals” Knowledge-Based Systems, 205(106152), 106152, 2020. https://doi.org/10.1016/j.knosys.2020.106152

Li, Y., Liu, Y., Guo, Y.-Z., Liao, X.-F., Hu, B., & Yu, T. “Spatio-temporal-spectral hierarchical graph convolutional network with semisupervised active learning for patient-specific seizure prediction”, IEEE Transactions on Cybernetics, 52(11), 12189–12204, 2022. https://doi.org/10.1109/TCYB.2021.3071860

Q. Wang, C. Huang, Q. Zeng, C. Li and T. Shu, "A Spatio-temporal Channel Attention Residual Network with Extended Series Mean Amplitude Spectrum for Epilepsy Detection," in IEEE Transactions on Cognitive and Developmental Systems, 2022, doi: 10.1109/TCDS.2022.3232121.

Xiong, Y., Li, J., Wu, D., Dong, F., Liu, J., Jiang, L., Cao, J., & Xu, Y. “Seizure detection algorithm based on fusion of spatio-temporal network constructed with dispersion index”, Biomedical Signal Processing and Control, 79(104155),2023. 104155 https://doi.org/10.1016/j.bspc.2022.104155

Li, C., Shao, C., Song, R., Xu, G., Liu, X., Qian, R., & Chen, X. “Spatio-temporal MLP network for seizure prediction using EEG signals”, Measurement: Journal of the International Measurement Confederation, 206(112278), 2023. 112278. https://doi.org/10.1016/j.measurement.2022.112278

L. Guo, D. Rivero, J. Dorado, J. R. Rabuñal, and A. Pazos, ‘‘Automatic epileptic seizure detection in EEGs based on line length feature and artificial neural networks,’’ J. Neurosci. Methods, vol. 191, no. 1, pp. 101–109, 2010

E. Juarez-Guerra, V. Alarcon-Aquino, and P. Gomez-Gil, ‘‘Epilepsy seizure detection in EEG signals using wavelet transforms and neural networks,’’ in New Trends in Networking, Computing, E-Learning, Systems Sciences, and Engineering. Berlin, Germany: Springer, 2015, pp. 261–269.

U. R. Acharya, S. L. Oh, Y. Hagiwara, J. H. Tan, and H. Adeli, ‘‘Deep convolutional neural network for the automated detection and diagnosis of seizure using EEG signals,’’ Comput. Biol. Med., vol. 100, pp. 270–278, Sep. 2017.

M. Zhou, C. Tian, R. Cao, B. Wang, Y. Niu, T. Hu, H. Guo, and J. Xiang, ‘‘Epileptic seizure detection based on EEG signals and CNN,’’ Frontiers Neuroinform., vol. 12, p. 95, Dec. 2018. [Online]. Available: https://www.frontiersin.org/articles/10.3389/fninf.2018.00095/full

C. Huang, W. Chen, and G. Cao, ‘‘Automatic epileptic seizure detection via attention-based CNN-BiRNN,’’ in Proc. IEEE Int. Conf. Bioinf. Biomed. (BIBM), Nov. 2019, pp. 660–663.

G. C. Jana, R. Sharma, and A. Agrawal, ‘‘A 1D-CNN-spectrogram based approach for seizure detection from EEG signal,’’ Proc. Comput. Sci., vol. 167, pp. 403–412, Jan. 2020. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1877050920307146

P. Boonyakitanont, A. Lek-Uthai, and J. Songsiri, ‘‘Automatic epileptic seizure onset-offset detection based on CNN in scalp EEG,’’ in Proc. IEEE Int. Conf. Acoust., Speech Signal Process. (ICASSP), May 2020, pp. 1225–1229.

Sun, B., Lv, J.-J., Rui, L.-G., Yang, Y.-X., Chen, Y.-G., Ma, C., & Gao, Z.-K. “Seizure prediction in scalp EEG based channel attention dual-input convolutional neural network” Physica A, 584(126376), 126376, 2021. https://doi.org/10.1016/j.physa.2021.126376

Chaisaen, R.; Banluesombatkul, N.; Boonchit, P.; Tatsaringkansakul, N.; Sudhawiyangkul, T.; Wilaiprasitporn, T. “EEGWaveNet: Multiscale CNN-Based Spatiotemporal Feature Extraction for EEG Seizure Detection”, IEEE Trans. Ind. Inform. 2022, 18, 5547–5557. [CrossRef]

Epmoghaddam, D.; Sheth, S.A.; Haneef, Z.; Gavvala, J.; Aazhang, B. “Epileptic seizure prediction using spectral width of the covariance matrix”. J. Neural Eng. 2022, 19, 026029. [CrossRef]

L. Vidyaratne, A. Glandon, M. Alam, and K. M. Iftekharuddin, ‘‘Deep recurrent neural network for seizure detection,’’ in Proc. Int. Joint Conf. Neural Netw. (IJCNN), Jul. 2016, pp. 1202–1207

H. Daoud and M. A. Bayoumi, ‘‘Efficient epileptic seizure prediction based on deep learning,’’ IEEE Trans. Biomed. Circuits Syst., vol. 13, no. 5, pp. 804–813, Oct. 2019.

Mansour, M., Khnaisser, F., & Partamian, H. “An explainable model for eeg seizure detection based on connectivity features”. arXiv preprint arXiv:2009.12566, 2020.

Linden, T., De Jong, J., Lu, C., Kiri, V., Haeffs, K., & Fröhlich, H. “An explainable multimodal neural network architecture for predicting epilepsy comorbidities based on administrative claims data”, Frontiers in Artificial Intelligence, 4, 610197, 2021. https://doi.org/10.3389/frai.2021.610197

Bijoy, E. H., Rahman, M. H., Ahmed, S., & Laskor, M. S. “An Approach to Detect Epileptic Seizure Using XAI and Machine Learning”, B (Doctoral dissertation, Brac University), 2022

Chapatwala, N., Paunwala, C. N., & Dalal, P. “An Explainable AI approach towards Epileptic Seizure Detection”, In 2022 IEEE 19th India Council International Conference (INDICON), (pp. 1-6), IEEE, November 2022.

Chowdhury, B. R., & Chowdhury, L. “Explaining decisions of quantum algorithm: Patient specific features explanation for epilepsy disease”, In Data-Intensive Research (pp. 63–81). Springer Nature Singapore, 2023.

Wang, Y., Yang, Y., Cao, G., Guo, J., Wei, P., Feng, T., Dai, Y., Huang, J., Kang, G., & Zhao, G. “SEEG-Net: An explainable and deep learning-based cross-subject pathological activity detection method for drug-resistant Epilepsy”, Computers in Biology and Medicine, 2022, 148(105703),105703. https://doi.org/10.1016/j.compbiomed.2022.105703

Raab, D., Theissler, A., & Spiliopoulou, M. “XAI4EEG: spectral and spatio-temporal explanation of deep learning-based seizure detection in EEG time series” Neural Computing and Applications, 35(14), 2023, 10051-10068. https://doi.org/10.1007/s00521-022-07809-x

Goldberger, A.L.; Amaral, L.A.; Glass, L.; Hausdorff, J.M.; Ivanov, P.C.; Mark, R.G.; Mietus, J.E.; Moody, G.B.; Peng, C.K.; Stanley, H.E. “PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals”. Circulation 2000, 101, E215–E220. [CrossRef]

Andrzejak, R.G.; Lehnertz, K.; Mormann, F.; Rieke, C.; David, P.; Elger, C.E. “Indications of nonlinear deterministic and finite-dimensional structures in time series of brain electrical activity: Dependence on recording region and brain state”, Phys. Rev. E—Stat. Phys. Plasmas Fluids Relat. Interdiscip. Top. 2001, 64, 061907. [CrossRef] [PubMed]

Craik, A.; He, Y.; Contreras-Vidal, J.L. Deep learning for electroencephalogram (EEG) classification tasks: A review. J. Neural Eng. 2019, 16, 031001. [Google Scholar] [CrossRef]

Sharma, R.; Sircar, P.; Pachori, R.B. Computer-aided diagnosis of epilepsy using bispectrum of EEG signals. In Application of Biomedical Engineering in Neuroscience; Springer: Singapore, 2019; pp. 197–220. [Google Scholar]

Battiti, R. (1994). Using Mutual Information for Selecting Features in Supervised Neural Net Learning. IEEE Trans. Neural Netw. 5, 537–550. doi:10.1109/72.298224

Yu, L., and Liu, H. (2004). Efficient Feature Selection via Analysis of Relevance and Redundancy. J. Mach. Learn. Res. 5, 1205–1224. doi:10.5555/1005332.1044700

Li, J.; Cheng, K.; Wang, S.; Morstatter, F.; Trevino, R.P.; Tang, J.; Liu, H. Feature Selection: A Data Perspective. ACM Comput. Surv. 2017, 50, 1–45. [Google Scholar] [CrossRef]

H. Sanz, C. Valim, E. Vegas, J.M. Oller, and F. Reverter, "SVM-RFE: selection and visualization of the most relevant features through non-linear kernels", BMC Bioinformatics, vol. 19, no. 1, p. 432, 2018.

Kohavi, R.; John, G.H. Wrappers for feature subset selection. Artif. Intell. 1997, 97, 273–324.

Sandri, M.; Zuccolotto, P. Variable Selection Using Random Forests. In Studies in Classification, Data Analysis, and Knowledge Organization; Springer: Berlin/Heidelberg, Germany, 2006; pp. 263–270.

O. Faust, Y. Hagiwara, T. J. Hong, O. S. Lih, and U. R. Acharya, “Deep learning for healthcare applications based on physiological signals: a review,” Computer Methods and Programs in Biomedicine, vol. 161, pp. 1–13, 2018.

P. Bizopoulos, G. I. Lambrou, and D. Koutsouris, “Signal 2image modules in deep neural networks for EEG classification,” in Proceedings of the 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 702–705, IEEE, Berlin, Germany, July 2019.

Harsh, S. ., Singh , D., & Pathak , S. (2021). Efficient and Cost-effective Drone – NDVI system for Precision Farming. International Journal of New Practices in Management and Engineering, 10(04), 14–19. https://doi.org/10.17762/ijnpme.v10i04.126

C. Park, G. Choi, J. Kim et al., “Epileptic seizure detection for multi-channel EEG with deep convolutional neural network,” in Proceedings of the 2018 International Conference on Electronics, Information, and Communication (ICEIC), pp. 1–5, IEEE, Jeju, Korea, February 2018.

F. Hassan, S.F. Hussain, S.M. Qaisar, "Epileptic Seizure Detection Using a Hybrid 1D CNN-Machine Learning Approach from EEG Data", Journal of Healthcare Engineering, vol. 2022, Article ID 9579422, 16 pages, 2022. https://doi.org/10.1155/2022/9579422

G.P.Jana, R. Sharma, A. Agrawal, A 1D-CNN-Spectrogram Based Approach for Seizure Detection from EEG Signal, Procedia Computer Science, Volume 167, 2020, Pages 403-412, ISSN 1877-0509, https://doi.org/10.1016/j.procs.2020.03.248.

M. Golmohammadi, S. Ziyabari, V. Shah, S. L. de Diego, I. Obeid, and J. Picone, “Deep architectures for automated seizure detection in scalp eegs,” 2017, https://arxiv.org/abs/1712.09776.

J. Cepukenas, C. Lin, and D. Sleeman, “Applying rule extraction and rule refinement techniques to (BlackBox) classifiers,” in Proceedings of the 8th International Conference on Knowledge Capture, p. 27, ACM, Palisades, NY, USA, October 2015.

S. Roy, I. Kiral-Kornek, and S. Harrer, “Deep learning enabled automatic abnormal EEG identification,” in Proceedings of the 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 2756–2759, IEEE, Honolulu, HI, USA, June 2018.

H. Ravi Prakash, M. Korostenskaja, E. M. Castillo et al., “Deep learning provides exceptional accuracy to ecog-based functional language mapping for epilepsy surgery,” BioRxiv, Article ID 497644, 2019.

S. Kumar and Y. U. Khan, "Biomedical Signals Classification with Transformer Based Model," 2023 International Conference on Power, Instrumentation, Energy and Control (PIECON), Aligarh, India, 2023, pp. 1-5, doi: 10.1109/PIECON56912.2023.10085908.

Chirasani SK, Manikandan S. A deep neural network for the classification of epileptic seizures using hierarchical attention mechanism. Soft Computing. 2022 Jun;26(11):5389-97.

B. Zhang, W. Wang, Y. Xiao et al., “Cross-subject seizure detection in EEGs using deep transfer learning,” Computational and Mathematical Methods in Medicine, vol. 2020, no. 13, Article ID 7902072, 8 pages, 2020.

Sarvi Zargar B, Karami Mollaei MR, Ebrahimi F, Rasekhi J. Generalizable epileptic seizures prediction based on deep transfer learning. Cognitive Neurodynamics. 2023 Feb;17(1):119-31.

Qi N, Piao Y, Yu P, Tan B. Predicting epileptic seizures based on EEG signals using spatial depth features of a 3D-2D hybrid CNN. Med Biol Eng Comput. 2023 Jul;61(7):1845-1856. doi: 10.1007/s11517-023-02792-4. Epub 2023 Mar 23. PMID: 36952120.